New local lockdown rules for England are due to be announced later.
The Liverpool City Region is expected to face the tightest restrictions under a new “three-tier” system, which will classify regions as being on “medium”, “high” or “very high” alert.
Steve Rotheram, the city region’s mayor, says negotiations have taken place through the night but “no deal” has been agreed yet.
Talks between local leaders in England and Westminster continue.
Liverpool recorded 600 cases per 100,000 people in the week ending 6 October. The average for England was 74.
The Liverpool City Region includes the local authority districts of Halton, Knowsley, Sefton, St Helens and Wirral, as well as Liverpool.
Gyms, casinos and pubs are among the businesses expected to be impacted by the top-level restrictions, with new curbs to be reviewed after a month.
Prime Minister Boris Johnson is chairing a meeting of the emergency Cobra committee “to determine the final interventions”.
He will then announce changes in the Commons, before speaking at a Downing Street press conference at 18:00 BST.
The prime minister is expected to be joined by Chancellor Rishi Sunak and England’s chief medical officer, Prof Chris Whitty.
Tougher measures were introduced in Scotland on Friday, including the closure of pubs and restaurants across the central belt, while the Welsh government has said the next few days could determine if “national measures” are implemented.
Under the new system for England, tier three is expected to involve the tightest restrictions.
BBC political correspondent Chris Mason said “today would provide some answers but it won’t provide them all”, with which category most regions fall into unlikely to be announced.
Mr Rotheram told BBC Breakfast he wanted “some surety from national government that if we hit some milestones we can come out of tier three very quickly”.
He said the government had been clear the Liverpool City Region would be placed in the highest category, with “no ifs, no buts”.
He said it had already been agreed that there would be more local control over track and trace and enforcement measures but there was still some reassurance needed on wider financial support for businesses that would be severely impacted by going into tier three.
Mr Rotheram has previously warned the government “can’t do lockdown on the cheap” and called for support for the city region and businesses forced to close by any measures.
Culture Secretary Oliver Dowden told Today the government was “not panicking” but taking “reasonable and proportionate measures”, adding that “we know there are challenges around hospitality”.
Calum Semple, professor of outbreak medicine at the University of Liverpool and a member of the Scientific Advisory Group for Emergencies (Sage), told BBC Breakfast: “Most of the outbreaks are happening within and between households and then after that, it’s in the retail and hospitality sector.
“So, the major issue here is to focus on the cities and areas with the largest outbreaks and sadly my home city of Liverpool is being hammered at the moment. These restrictions are necessary.”
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